Can I make this Mac and Cheese Meatloaf Casserole ahead of time?

Yes! You can prepare the entire casserole up to 24 hours in advance. Simply assemble it, cover tightly with foil, and refrigerate until ready to bake. When you're ready, let it sit at room temperature for 15–20 minutes before baking as directed.

What should I serve with this casserole?

This dish is rich and hearty, so pair it with something light and fresh. A crisp green salad or some roasted broccoli works perfectly to balance the creamy cheese and savory meat.

Can I use different pasta shapes?

Absolutely. While elbow macaroni is classic, other small pasta shapes like shells , rotini , or penne also work well. Just make sure to cook them al dente to avoid over-softening during baking.

How do I know when the meatloaf is fully cooked?

Use a meat thermometer to check the center of the casserole. The meatloaf layer should reach an internal temperature of 160°F (71°C) . This ensures it's cooked through and safe to eat.

Mac and Cheese Meatloaf Casserole – Creamy, Cheesy Comfort

Description

If you’re craving comfort food that really satisfies, this Mac and Cheese Meatloaf Casserole combines two family favorites into one unforgettable dish. A tender, flavorful meatloaf base is topped with creamy, cheesy macaroni and baked until bubbling and golden. It’s perfect for family dinners, potlucks, or anytime you want a hearty meal that brings people together.

Ingredients

Scale

Meatloaf Base:

2 pounds lean ground beef
30 Ritz crackers, crushed
2 ounces Lipton onion soup mix
2 large eggs
1 cup ketchup
1 cup Sweet Baby Ray’s Hickory & Brown Sugar barbecue sauce

Macaroni Layer:

3 cups dry macaroni noodles
2 cups milk
1 can (10.5 oz) condensed cheddar cheese soup
1 teaspoon salt
1 teaspoon pepper
1 tablespoon garlic powder
1 tablespoon onion powder
4 cups shredded mozzarella and cheddar cheese blend (divided)

Instructions

Preheat oven to 350°F. Lightly grease a 9×13-inch baking dish.
Make the sauce: In a bowl, combine ketchup and barbecue sauce. Set aside.
Prepare the meatloaf: Mix ground beef, crushed crackers, onion soup mix, eggs, and ½ cup of the sauce. Press into baking dish. Spread remaining sauce on top.
Bake the meatloaf base: Bake uncovered for 30 minutes.
Cook the macaroni: While the meatloaf bakes, cook macaroni noodles per package instructions. Drain and set aside.
Make the cheese sauce: In a bowl, whisk milk, cheddar cheese soup, salt, pepper, garlic powder, and onion powder. Stir in noodles and 2 cups cheese.
Assemble the casserole: Spread macaroni mixture over meatloaf, top with remaining 2 cups cheese.
Finish baking: Return to oven for 17–20 minutes, until cheese is melted and golden.
Cool and serve: Let rest for 5–10 minutes before slicing.

Notes

Make it gluten-free: Use gluten-free crackers and pasta. Replace cheddar cheese soup with a gluten-free cheese sauce.
Add-ins: Add a pinch of smoked paprika to the cheese sauce or sautéed onions/jalapeños to the meatloaf for extra flavor.

Prep Time: 25 minutes
Cook Time: 50 minutes
Category: Main Course
Method: Baking
Cuisine: American

Nutrition

Calories: 620
Fat: 36g
Carbohydrates: 38g
Protein: 35g

Keywords: mac and cheese meatloaf casserole, cheesy meatloaf bake, comfort food casserole, mac and cheese layered meatloaf