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Golden baked chicken and vegetable casserole with biscuit topping in a glass dish

Chicken and Vegetable Casserole


  • Author: Charlotte
  • Total Time: 55 minutes
  • Yield: 6 servings 1x

Description

This Chicken and Vegetable Casserole is a warm, wholesome dish that’s perfect for using up leftover chicken or turkey. With a soft, savory crust and a creamy vegetable filling, it’s a comforting family dinner that comes together with simple pantry staples. Ideal for make-ahead meals or weeknight dinners.


Ingredients

Scale

For the Crust:

  • 1/2 cup butter, softened
  • 1 cup sour cream
  • 1 large egg
  • 1 cup all-purpose flour
  • 1 teaspoon baking powder
  • 1 teaspoon salt
  • 1/2 teaspoon rubbed sage

For the Filling:

  • 1 package (16 ounces) frozen mixed vegetables, thawed
  • 2 cups cubed cooked chicken or turkey
  • 1 can (10.75 ounces) condensed cream of mushroom soup (undiluted)
  • 1/2 cup chopped onion
  • 1/2 cup shredded cheddar cheese

Ingredient Tip: Use leftover rotisserie chicken or Thanksgiving turkey to save prep time. Cream of chicken or celery soup also works well.


Instructions

  1. Preheat oven: Set to 400°F. Lightly grease a 3-quart baking dish.
  2. Make the crust: In a bowl, cream butter and sour cream until smooth. Beat in the egg. In another bowl, whisk together flour, baking powder, salt, and sage. Add to wet mixture and stir until a thick batter forms. Spread evenly in baking dish.
  3. Prepare filling: In a large bowl, combine thawed vegetables, cooked chicken or turkey, cream of mushroom soup, and chopped onion. Mix well.
  4. Assemble: Pour filling over the crust and spread evenly. Top with shredded cheddar cheese.
  5. Bake: Bake uncovered for 35-40 minutes until bubbly and golden. The crust should be set, and cheese melted.
  6. Rest: Let sit for 5 minutes before serving for easier slicing.

Notes

  • Make Ahead: Prepare the full casserole and refrigerate (unbaked) up to 24 hours. Let sit at room temp 20 minutes before baking.
  • Storage: Store leftovers in an airtight container in the fridge for up to 3 days.
  • Reheating: Microwave individual portions or reheat covered in a 325°F oven until warmed through.
  • Swaps: Use cream of chicken or celery soup instead of mushroom for different flavor profiles.
  • Prep Time: 15 minutes
  • Cook Time: 40 minutes
  • Category: Meat Casseroles
  • Method: Baking, Oven
  • Cuisine: American

Nutrition

  • Calories: 410
  • Sugar: 4g
  • Sodium: 640mg
  • Fat: 28g
  • Saturated Fat: 13g
  • Carbohydrates: 18g
  • Fiber: 3g
  • Protein: 22g
  • Cholesterol: 120mg

Keywords: chicken vegetable casserole, leftover chicken bake, easy weeknight casserole, rotisserie chicken recipe