Easy Chicken and Vegetable Casserole Recipe

This Chicken and Vegetable Casserole is a creamy, savory dish that brings cozy comfort to your dinner table with minimal effort. It’s the perfect solution when you need a reliable, fuss-free meal that doesn’t require a trip to the store. Using simple ingredients like frozen vegetables, sour cream, and cooked chicken, you can create a filling, flavor-packed dinner in under an hour.

The star of this easy Chicken and Vegetable Casserole is its soft, biscuit-like crust made with sour cream, butter, and a touch of sage for added depth. Underneath, you’ll find a deliciously creamy vegetable and chicken filling that’s loaded with color and flavor. Topped with gooey cheddar cheese, every bite is rich, satisfying, and family-approved.

Whether you’re making the most of leftover chicken, prepping for a busy weeknight, or craving a creamy Chicken and Vegetable Casserole, this dish delivers. It’s comforting, quick to prepare, and reheats beautifully. Let’s dive into the details of this delicious weeknight dinner casserole.

Whether you’re making the most of leftover chicken, prepping for a busy weeknight, or craving a creamy chicken and vegetable bake, this dish delivers. For more comforting casseroles, check out this Chicken Broccoli Pasta Casserole.

Table of Contents

Why You’ll Love This Chicken and Vegetable Casserole

Wondering why this Chicken and Vegetable Casserole should be your next go-to dinner? Here are all the reasons this easy dish belongs in your recipe rotation:

• Incredibly Easy: No fancy ingredients or complicated prep. This easy Chicken and Vegetable Casserole uses everyday items like frozen mixed vegetables, condensed soup, and sour cream. Perfect for busy weeknights when time is short and you need something fast and foolproof.
• Rich and Creamy: The combination of sour cream and cream of mushroom soup creates a smooth, comforting sauce with amazing flavor. It’s a creamy Chicken and Vegetable Casserole that doesn’t require a separate roux or heavy cream.
• Perfect for Leftovers: Got leftover roast chicken or turkey? This recipe gives it new life. It’s one of the best ways to make the most of post-holiday meals or a store-bought rotisserie chicken. A truly smart leftover chicken recipe!
• A Complete Meal in One Dish: You get protein, vegetables, and a biscuit-style crust all in one pan. Serve it on its own or pair it with a side salad for a balanced meal. It’s a true weeknight dinner casserole that checks every box.
• Family-Friendly Flavor: Kids and adults love this one. The cheesy topping and creamy filling keep things comforting and satisfying, while the mild flavors make it a crowd-pleaser.

This casserole is simple, satisfying, and made to please. Ready to give it a try?

It’s one of the best ways to make the most of post-holiday meals or a store-bought rotisserie chicken. If you enjoy meals like this, you’ll also love our easy Chicken Rice Broccoli Casserole.

Ingredients You’ll Need

The beauty of this easy Chicken and Vegetable Casserole is its reliance on simple, accessible ingredients. Here’s what you’ll need:

For the Creamy Casserole Filling:

• Cubed Cooked Chicken or Turkey
  This is the heart of the casserole. You can use freshly cooked chicken, but leftover chicken or even rotisserie chicken makes things quick and convenient. Turkey also works perfectly, especially after the holidays.
• Frozen Mixed Vegetables
  A colorful mix of peas, carrots, corn, and green beans adds nutrients, flavor, and texture. Make sure to thaw the vegetables and pat them dry to avoid watering down the filling.
• Condensed Cream of Mushroom Soup (Undiluted)
  This is the creamy binder that holds the filling together. Be sure not to add water or milk, using it undiluted keeps the mixture thick and rich. You can substitute with cream of chicken or celery if you prefer.
• Chopped Onion
  Adds savory depth and balances the richness of the cream soup. Yellow or white onions work best for a mellow flavor.
• Shredded Cheddar Cheese
  The cheesy topping brings everything together. Sharp cheddar gives a stronger flavor, while mild is more subtle. For best results, shred your own cheese, pre-shredded varieties often contain anti-caking agents that prevent smooth melting.

For the Savory Biscuit Topping:

• All-Purpose Flour
  Forms the base of the topping, giving it the structure it needs to bake into a tender crust.
• Baking Powder
  Adds lightness and rise to the topping, creating that fluffy, biscuit-like texture.
• Salt & Rubbed Sage
  Salt enhances flavor, and sage brings an earthy taste that pairs beautifully with chicken and creamy fillings.
• Softened Butter
  Makes the topping soft and rich. Make sure it’s fully softened so it mixes smoothly with the other ingredients.
• Sour Cream
  This is the secret ingredient. It adds moisture, a slight tang, and ensures a tender, flavorful crust.
• Large Egg
  Helps bind everything together so the topping holds its shape as it bakes.

These ingredients come together to create a cozy, flavorful chicken and vegetable casserole that tastes like a warm hug on a plate.

How to Make Chicken and Vegetable Casserole (Step-by-Step)

Follow these simple steps to create a warm, flavorful chicken and vegetable casserole that’s perfect for any night of the week.

Step 1: Prep and Preheat

Preheat your oven to 400°F (200°C). Lightly grease a 9×13 inch baking dish with butter or nonstick spray. This will help prevent sticking and make cleanup easier.

Step 2: Mix the Casserole Filling

In a large bowl, combine the following:

• 2 cups cubed cooked chicken or turkey
• 1 package (16 oz) thawed frozen mixed vegetables
• 1 can (10.75 oz) undiluted cream of mushroom soup
• ½ cup chopped onion

Stir everything together until all ingredients are evenly coated. Pour the mixture into the greased baking dish and spread it into an even layer. This creamy base creates the heart of your easy chicken casserole.

Step 3: Prepare the Biscuit Topping

In a medium bowl, whisk together:

• 1 cup all-purpose flour
• 1 teaspoon baking powder
• 1 teaspoon salt
• ½ teaspoon rubbed sage

Add ½ cup softened butter, and use your fingers or a pastry blender to work it into the dry ingredients. The mixture should look like coarse crumbs. This will form the base of your soft, golden crust.

Step 4: Finish the Topping Batter

In a small bowl, whisk together:

• 1 large egg
• 1 cup sour cream

Pour this wet mixture into the flour mixture. Stir gently until a thick batter forms. Avoid overmixing, this keeps the topping light and fluffy.

Step 5: Assemble the Casserole

Using a spoon, drop spoonfuls of the biscuit batter over the filling. It’s okay if some filling shows through, the rustic look is part of its charm. You’re layering flavor and texture in one easy step.

Step 6: Bake to Golden Perfection

Sprinkle ½ cup shredded cheddar cheese over the top. Bake the casserole uncovered for 30–35 minutes, or until the topping is golden brown and the filling is bubbling around the edges. The cheese should melt beautifully and form a light crust.

Step 7: Rest and Serve

Remove the dish from the oven and let it rest for 5 to 10 minutes. This helps the filling thicken slightly and makes it easier to slice and serve. Enjoy your warm, satisfying creamy chicken and vegetable bake.

Expert Tips, Tricks, and Variations

Want to make your Chicken and Vegetable Casserole even better? These expert tips and variations will help you get the most out of every bite, whether you’re adjusting for ingredients on hand or just looking to personalize the dish.

Tips for Success

• Don’t Overmix the Topping
  For a tender, fluffy crust, mix the biscuit topping just until the flour disappears. Overmixing can make it dense and chewy instead of light and soft.
• Thaw Your Veggies
  Always thaw and pat dry frozen vegetables before adding them. This keeps excess water from making the casserole runny or soggy.
• Use Room Temperature Ingredients
  Let the butter, sour cream, and egg sit out for a bit before mixing the topping. This helps them combine more smoothly and evenly, resulting in a better texture.

Recipe Variations & Substitutions

• Different Soups
  Swap the cream of mushroom soup with cream of chicken or cream of celery for a new flavor twist while keeping that creamy texture.
• Add More Veggies
  Want more nutrition or variety? Stir in sautéed mushrooms, fresh spinach, or small broccoli florets for extra color and taste.
• Change the Cheese
  Cheddar is classic, but feel free to use Monterey Jack, Colby, or even a Swiss cheese blend for a different cheesy profile.
• Herb Variations
  Try adding a pinch of thyme or rosemary to the topping or filling. These herbs pair beautifully with poultry and can add a fresh, savory depth.

These tweaks let you transform the same base into a totally new chicken casserole with sour cream every time you make it.

Want more comforting bakes? Try this flavorful Swiss Chicken Casserole, made with creamy sauce and gooey cheese.

Serving and Storage

This Chicken and Vegetable Casserole is comforting, filling, and easy to prepare, but it’s also flexible when it comes to serving and storing. Here’s how to get the most out of your meal.

What to Serve with Chicken and Vegetable Casserole

This is a hearty meal on its own, but it pairs beautifully with simple sides. Try a crisp green salad with a vinaigrette for a fresh contrast. You can also serve it with crusty bread or warm dinner rolls, perfect for soaking up the creamy filling.

Want to make it extra cozy? A side of roasted green beans or sautéed spinach adds a healthy touch without much extra work.

How to Store and Reheat

If you have leftovers, you’re in luck, this dish stores and reheats well.

• Store: Place leftovers in an airtight container in the refrigerator for up to 3 days.
• Reheat: Warm single portions in the microwave for 1–2 minutes. For larger portions, cover the baking dish with foil and heat in a 350°F (175°C) oven until hot throughout.

The crust stays surprisingly tender even after reheating, making it a reliable weeknight dinner casserole for the days ahead.

Make-Ahead & Freezer Instructions

Can you freeze this chicken and vegetable casserole? Absolutely.

• Assemble the full dish but do not bake it.
• Cover tightly with plastic wrap, then with foil, and freeze for up to 3 months.
• When ready to cook, remove the plastic wrap, re-cover with foil, and bake from frozen at 375°F (190°C) for 50-60 minutes.
• Remove foil for the last 15 minutes to help the topping turn golden brown and bubbly.

This make-ahead method is perfect for busy families or meal prep days.

Chicken and Vegetable Casserole FAQs

Have questions about making the perfect Chicken and Vegetable Casserole? Here are clear answers to the most common ones, based on what home cooks often ask.

Your New Favorite Weeknight Comfort Food

I hope this easy Chicken and Vegetable Casserole becomes a new comfort food classic in your home! With its creamy filling, savory biscuit topping, and family-friendly flavors, it’s the kind of meal you’ll want to make again and again.

Whether you’re using up leftovers or planning ahead for a busy night, this weeknight dinner casserole delivers every time. It’s satisfying, simple, and endlessly customizable.

If you tried this recipe, please leave a comment and a star rating below! I’d love to hear how it turned out for you, what tweaks you made, or how your family liked it. Your feedback helps others and inspires more great meals.

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